On an HLA Null Allele Case Study

A recent case study report describes the discovery of a novel HLA null allele and its effect on protein synthesis and gene expression (Rozar, 2021).  We occasionally deliver HLA reports that include null alleles.  This case study highlights…
hla imgt database

How Did We Discover a Novel HLA Allele?

Intro One of the pleasures of owning a genomics company is assisting client researchers with new discoveries.  Recently, one of our clients completed an 11-loci, 4-field HLA typing project for a clinical trial project.  Using Illumina Next…
SARS-COV2 spike protein

HLA Susceptibility in SARS-CoV-2

Intro Nguyen et al. recently published a paper "Human leukocyte antigen susceptibility map for SARS-CoV-2" in the Journal of Virology  Using in-silico methods, they assessed the binding affinities of MHC Class I alleles (HLA-A, HLA-B,…