Chromosome 6 HLA gene

The Functions of HLA Genes

The Human Leukocyte Antigen (HLA) system is a group of genes that plays a crucial role in the immune system. Located on the short arm of chromosome 6, the HLA complex is part of the Major Histocompatibility Complex (MHC) in humans, which is…
Immunology research

Leveraging the Power of 4-field HLA Typing and the IMGT Database for Immunology Research

The world of immunology has been transformed in recent years, thanks in part to advances in the study of human leukocyte antigen (HLA) typing. In this post, we will delve into how researchers in the immunology space can take advantage of the…
IMGT database

How to Search for Variants in a 4-Field HLA Typing Report Against the IMGT Database

The International ImMunoGeneTics Information System (IMGT) is a high-quality, integrated database that provides comprehensive information on immunoglobulins (IG), T cell receptors (TR), and major histocompatibility complex (MHC) molecules. In…
T-cells

Unraveling the Synergy between B and T Cell Immunology and HLA Typing

The immune system is a sophisticated and intricate network of cells and molecules that work together to protect the body from pathogens. B and T cells are critical components of the adaptive immune response, which specifically targets foreign…
CAR-T cell therapy

The Intricate Interplay of HLA Genes, HLA Typing, and CAR-T Cell Therapy: A Deep Dive

The field of immunotherapy has witnessed significant advancements in recent years, with chimeric antigen receptor CAR-T cell therapy emerging as a revolutionary treatment modality for certain hematological malignancies. CAR-T cells are genetically…
HLA epitopes

Unraveling the Mysteries of HLA Typing: 3 Groundbreaking Allele Discoveries

Human Leukocyte Antigen (HLA) typing has revolutionized the fields of immunology, organ transplantation, and disease association research. It is a method for identifying the genetic variations in HLA genes that determine an individual's unique…
HLA chromosome 6

The Top 5 Misconceptions with HLA Genes and Immunology

The Human Leukocyte Antigen (HLA) system is a complex genetic system that plays a critical role in the immune response. It is essential for the identification and elimination of foreign substances in the body. Despite its importance, there are…
Laboratory tubes used for drug discovery

Diving into the History of HLA Genes and Their Impact on Drug Discovery

The Human Leukocyte Antigen (HLA) system, a key component of our immune system, is responsible for the recognition and presentation of foreign antigens to T-cells. The HLA system has emerged as a vital player in transplant compatibility, autoimmune…
HLA cells

What are the Differences Between 2-field and 4-field Reporting for HLA Typing?

As a researcher, you are likely familiar with the importance of HLA typing in various clinical applications, such as transplantation, disease association studies, and pharmacogenomics. Given the critical role that HLA typing plays in these areas,…
HLA-G in cancer

What is the Impact of HLA Typing on Cancer Immunotherapy?

This post explores the influence of Human Leukocyte Antigen (HLA) typing on cancer immunotherapy, detailing its role in developing personalized treatments and improving patient outcomes. We discuss the latest research in the field, including…
HLA DRB1 diseases

HLA Typing: Disease States Associated with HLA-DRB1/3/4/5 Genes

This blog post presents an overview of the disease states associated with variations in the human leukocyte antigen (HLA) DRB1, DRB3, DRB4, and DRB5 genes. We will discuss the importance of HLA typing in the context of these diseases, the various…
HLA disease associations

HLA Typing: Unlocking the Secrets of the Human Immune System

HLA Typing, or Human Leukocyte Antigen typing, is a powerful tool in the world of medical research and clinical applications. As the cornerstone of understanding the human immune system, HLA Typing has become increasingly essential for successful…
HLA-B27 disease associations

HLA Typing: Exploring Disease States Associated with Variants of the HLA-B Gene

Human Leukocyte Antigen (HLA) typing is an essential tool in understanding genetic susceptibility to diseases, as it identifies specific alleles associated with various disease states. Among the HLA genes, the HLA-B gene has been extensively…
HLA chromosome 6

Unraveling the Complexity of HLA Genes: Disease States and Their Genetic Underpinnings

The Human Leukocyte Antigen (HLA) complex, a crucial component of the immune system, is known for its staggering genetic diversity. Located on the short arm of Chromosome 6, the HLA complex encodes for cell-surface proteins responsible for the…
Autoimmune diseases

Decoding HLA-A: Common Allele Variants and Their Clinical Implications

The Human Leukocyte Antigen (HLA) system, a group of genes within the Major Histocompatibility Complex (MHC), plays a critical role in the immune response. HLA class I molecules, including HLA-A, -B, and -C, are responsible for presenting intracellular…

Collecting and Shipping PBMC and Cell Pellet Samples for HLA Typing

Peripheral blood mononuclear cells (PBMCs) and cell pellets are common sources of DNA for human leukocyte antigen (HLA) typing in immune-related disease research. However, collecting these samples from donors can pose challenges that researchers…
HLA nomenclature
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The Benefits of 4-Field Resolution for HLA Typing

Human leukocyte antigen (HLA) typing is an essential component of research into immune-related diseases, including autoimmune disorders and infectious diseases. HLA genes are highly polymorphic, meaning that they come in many different forms,…
HLA-DRB5

The HLA-DRB5 Gene

The HLA-DRB5 gene is a human leukocyte antigen gene located on chromosome 6. It is a part of the major histocompatibility complex (MHC) family, which helps the immune system recognize and respond to foreign substances. HLA-DRB5 is involved in…
HLA-G

The HLA-G Gene

HLA-G is a Major Histocompatibility Complex (MHC) gene located on human chromosome 6. The gene is a member of the HLA-A, -B, -C, -E, -F, and -G family of molecules, which are involved in the regulation of the immune system and other cellular…
HLA-DQB1

The HLA-DQB1 Gene

The HLA-DQB1 gene is an important component of the human leukocyte antigen (HLA) system, a group of genes that regulate the immune system. It is located on chromosome 6 in humans and encodes a class II major histocompatibility complex (MHC)…