The HLA-DQA1 Gene
The HLA-DQA1 gene is a member of the HLA gene family, which is located on the short arm of chromosome 6. The gene encodes proteins that are involved in the immune response and are part of the major histocompatibility complex (MHC). HLA-DQA1…
The HLA-DPB1 Gene
The HLA-DPB1 gene is a gene located on the short arm of the sixth chromosome (6p21.3) and is part of the human leukocyte antigen (HLA) major histocompatibility complex (MHC) locus. The HLA-DPB1 gene is important for the immune system as it is…
The HLA-DPA1 Gene
The HLA-DPA1 gene belongs to the human leukocyte antigen (HLA) family and is located on chromosome 6. It plays a key role in the immune system by helping the body to recognize and respond to foreign antigens. The gene provides instructions for…
The HLA-DRB4 Gene
The HLA-DRB4 gene is a member of the human leukocyte antigen (HLA) family, which is responsible for coding proteins that help the body’s immune system recognize and fight off foreign substances, such as viruses and bacteria. The HLA-DRB4 gene,…
The HLA-DRB3 Gene
HLA-DRB3 is a human leukocyte antigen (HLA) gene located on chromosome 6. It codes for a polymorphic cell surface glycoprotein known as the DRB3 molecule. This molecule is a member of the MHC class II family of immune-related proteins and is…
The HLA-DRB1 Gene
The HLA-DRB1 gene is a major histocompatibility complex (MHC) gene located on human chromosome 6. It is a polymorphic gene, meaning that it has many different forms that vary from person to person. The HLA-DRB1 gene encodes for the HLA-DRB1…
The HLA-C Gene
The HLA-C gene is a major histocompatibility complex (MHC) class I gene located on human chromosome 6. It is a member of the MHC Class I family of genes, which are responsible for the recognition and presentation of antigens to the immune system.…
Understand How To Best Utilize HLA Typing
HLA typing is a laboratory test used to determine the type of human leukocyte antigen (HLA) that an individual has. HLA are proteins found on the surface of white blood cells, and they play an important role in how our immune system recognizes…
The HLA-B Gene
The human leukocyte antigen (HLA) system is a group of genes located on chromosome 6 that play a crucial role in the immune system. The HLA-B gene is one of the many genes that make up the HLA system, and it is responsible for encoding a protein…
The HLA-A Gene
The human leukocyte antigen (HLA) system is a critical component of the immune system and an essential subject of medical research. The major histocompatibility complex (MHC) is an integral part of the HLA system, and the HLA-A gene is a key…
HLA Typing and HLA Genes in Research: A Primer
Immunology is the study of the immune system, which includes both innate and adaptive immunity. This includes antibodies, specialized proteins that recognize foreign invaders such as bacteria or viruses; T cells, specialized white blood cells…
Nanopore Long-Reads Coming to HLA
GenDx announced NGS-Turbo, a long-read HLA sequencing product for Nanopore instruments. Although we will have to see the actual protocol in practice, HLA sequencing with Nanopore long-reads should offer significant benefits in relation to short-read…
Novel HLA Allele Identified
In May 2020, we reported on the likely discovery of a novel HLA-B allele, a finding that would later unfold into a captivating tale of scientific collaboration and the importance of data archiving. During our initial analysis, we performed HLA…
On an HLA Null Allele Case Study
A recent case study report describes the discovery of a novel HLA null allele and its effect on protein synthesis and gene expression (Rozar, 2021). We occasionally deliver HLA reports that include null alleles. This case study highlights…
How Did We Discover a Novel HLA Allele?
One of the pleasures of owning a genomics company is assisting client researchers with new discoveries. Recently, one of our clients completed an 11-loci, 4-field HLA typing project for a clinical trial project. Using Illumina Next Generation…
HLA Susceptibility in SARS-CoV-2
Nguyen et al. recently published a paper "Human leukocyte antigen susceptibili8ty map for SARS-CoV-2" in the Journal of Virology. Using in-silico methods, they assessed the binding affinities of MHC Class I alleles (HLA-A, HLA-B, HLA-C) with…
The Cost of HLA Typing
At The Sequencing Center, one of the main services that we provide to pharmaceutical, academic, and clinical researchers is HLA Typing. HLA Typing (human leukocyte antigen) is most commonly leveraged for matching patients and donors for bone…
Find Your Perfect Match: Using HLA Typing For Successful Organ Transplants
Within clinical environments, making decisions based on precise and comprehensive data is paramount in practicing high-quality medicine. One of the more complex clinical procedures involves organ transplants. Organ transplant surgery, a high-risk…