Using AlphaFold for Modeling HLA-Peptide Complexes in the Context of HLA Typing

The human leukocyte antigen (HLA) system plays a crucial role in the adaptive immune response, with HLA proteins presenting peptides derived from endogenous and exogenous proteins to T cells. Accurate modeling of the structural interactions…
Artificial intelligence

Leveraging AI and ML in HLA Typing: A New Frontier in Health Science

Our understanding of human health is constantly evolving, and at the cutting edge of this expansion is the increasingly critical role of Human Leukocyte Antigen (HLA) typing. This method, key in immunogenetic research, involves identifying specific…
HLA nomenclature

The Benefits of 4-Field Resolution for HLA Typing

Human leukocyte antigen (HLA) typing is an essential component of research into immune-related diseases, including autoimmune disorders and infectious diseases. HLA genes are highly polymorphic, meaning that they come in many different forms,…
Novel HLA allele identifiedThe Sequencing Center

Novel HLA Allele Identified

In May 2020, we reported on the likely discovery of a novel HLA-B allele, a finding that would later unfold into a captivating tale of scientific collaboration and the importance of data archiving. During our initial analysis, we performed HLA…
hla imgt database

How Did We Discover a Novel HLA Allele?

One of the pleasures of owning a genomics company is assisting client researchers with new discoveries.  Recently, one of our clients completed an 11-loci, 4-field HLA typing project for a clinical trial project.  Using Illumina Next Generation…
the genome sequencing process

The Genome Sequencing Process

The process of sequencing a genetic sample can often feel like a confusing and fragmented process, with each individual step being performed by different vendors before finally ending up with a sequenced genome. In fact, it was our frustration…
Bacterial Genome Sequencing

Targeted Sequencing in Bacterial Research

In the new age of genomics, researching specific genes within a genome has become a common focal point of interest. This is prevalent in bacterial research fields primarily because it provides deep insight into specific functions and attributes…
Cancer Research

Cancer Gene Databases You Need

With any research, it all starts with the data. Cancer is no exception here. The incredible amount of funding that has been pushed into cancer research has produced many different databases that have identified genes that correlate with common…

5 Common Myths of Genome Sequencing

Having many customers in various fields, we hear a lot of interesting myths that are persistent across each of them. Some come from misguidance of other companies in the sales process, other myths are rooted in legacy in which the landscape…