Nanopore Long-Reads Coming to HLA

GenDx announced NGS-Turbo, a long-read HLA sequencing product for Nanopore instruments. Although we will have to see the actual protocol in practice, HLA sequencing with Nanopore long-reads should offer significant benefits in relation to short-read…

Novel HLA Allele Identified

In May, 2020, we reported on the likely discovery of a novel HLA-B allele (https://bit.ly/3TsmmtY). At that time, we performed HLA typing and sequence alignments against the then current version of the IMGT/HLA database, namely, v.3.38.0. The…

Illumina Announces Long Reads

Illumina recently announced the upcoming availability of long-read technology at the 40th Annual J.P. Morgan Healthcare Conference, in a press release and on Illumina's Genomics Research Hub.  The new long-read sequencing assay is code-named…

On an HLA Null Allele Case Study

A recent case study report describes the discovery of a novel HLA null allele and its effect on protein synthesis and gene expression (Rozar, 2021).  We occasionally deliver HLA reports that include null alleles.  This case study highlights…

Celebrating 5 Years of Sequencing

We are celebrating 5 years in business!  We are so grateful to our clients worldwide who have helped us build our business and successfully hit the 5-year mark.  Without your continued business, it would not have been possible to make it this…

The Sequencing Center Now Offers Long-Read Sequencing Services

FOR IMMEDIATE RELEASE Fort Collins, Colorado, 10/12/2020 - The Sequencing Center, a genome sequencing service provider for biological and clinical research, announced today that it will offer long-read sequencing services to supplement its…
hla imgt database

How Did We Discover a Novel HLA Allele?

Intro One of the pleasures of owning a genomics company is assisting client researchers with new discoveries.  Recently, one of our clients completed an 11-loci, 4-field HLA typing project for a clinical trial project.  Using Illumina Next…
SARS-COV2 spike protein

HLA Susceptibility in SARS-CoV-2

Intro Nguyen et al. recently published a paper "Human leukocyte antigen susceptibili8ty map for SARS-CoV-2" in the Journal of Virology  Using in-silico methods, they assessed the binding affinities of MHC Class I alleles (HLA-A, HLA-B,…
Multiplexed samples reduces cost

Cost Savings with Multiplex Samples

Multiplex Sequencing Multiplexing is a method of combining two or more samples in a single sequencing run.  Multiplexing can increase the throughput of sequencing runs and save money at the same time. Conceptually, multiplexing is a fairly…
hla typing

The Cost of HLA Typing

At The Sequencing Center, one of the main services that we provide to pharmaceutical, academic, and clinical researchers is HLA Typing. HLA Typing (human leukocyte antigen) is most commonly leveraged for matching patients and donors for bone…

Bacteriophage DNA Extraction Protocol

We routinely perform bacteriophage whole genome sequencing.  However, we do not currently offer phage DNA extraction services.  Instead, researchers perform phage DNA extraction at their own facilities and then ship purified gDNA to our sequencing…
The Ultimate Guide to Genome Sequencing

With 510% Revenue Growth Powered by Pfizer, Eli Lilly, and USDA, The Sequencing Center Sets Eyes on Larger $9B Genetics Market

FOR IMMEDIATE RELEASE Fort Collins, Colorado, 01/10/2019 - The Sequencing Center, a genome sequencing provider for biological and clinical research, announced a year-over-year revenue growth of 510%. Throughout the year, The Sequencing Center…
Genome Expression Sequencing

The Influence of Genetics on Clinical Research

Like any new technology adoption curve, genome sequencing has gone through the typical hype cycle. We start to leverage a new technology and it becomes massively hyped as the thing that will "change everything" only to realize that we don't…
clinical diagnostics

Increasing Access to Genome Sequencing for Clinical Diagnostics

As genome sequencing continues to decrease in price and increase in demand, the desire for many clinical organizations to leverage genome sequencing as a clinical diagnostic means continues to get traction. In a recent change, the California…

Genome Sequencing Facility Makes Move to Commoditize DNA Extraction By Offering Free DNA Extraction

FOR IMMEDIATE RELEASE Fort Collins, Colorado, 5/17/2018 - The Sequencing Center, a next generation genome sequencing company, made a big move today by announcing free DNA extraction for any genome sequencing project that comes through their…
genome vs exome

Genome, Exome… What’s the Difference?

Genome sequencing is all over the news lately, especially with commercial companies offering sequencing to explore a customer's ethnic background, recommended diets and fitness plans, and reveal what kinds of diseases they might potentially…
HLA typing

Find Your Perfect Match: Using HLA Typing For Successful Organ Transplants

Within clinical environments, making decisions based on precise and comprehensive data is paramount in practicing high-quality medicine. One of the more complex clinical procedures involves organ transplants. Organ transplant surgery, a high-risk…
How to submit a sample for genome sequencing

How to Submit a Sample for Genome Sequencing

At The Sequencing Center, we receive hundreds of samples every month, and while most of the samples are primed and ready for sequencing, it’s easy for our clients to miss some key preparation steps. In order to get the best results from your…
the genome sequencing process
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The Genome Sequencing Process

The process of sequencing a genetic sample can often feel like a confusing and fragmented process, with each individual step being performed by different vendors before finally ending up with a sequenced genome. In fact, it was our frustration…