Navigating Challenges and Considerations for Collecting and Shipping PBMC and Cell Pellet Samples in HLA Typing Research

Peripheral blood mononuclear cells (PBMCs) and cell pellets are common sources of DNA for human leukocyte antigen (HLA) typing in immune-related disease research. However, collecting these samples from donors can pose challenges that researchers…

The Benefits of 4-Field Resolution for HLA Typing in Immune-Related Disease Research

Human leukocyte antigen (HLA) typing is an essential component of research into immune-related diseases, including autoimmune disorders and infectious diseases. HLA genes are highly polymorphic, meaning that they come in many different forms,…

The HLA-DRB5 Gene

The HLA-DRB5 gene is a human leukocyte antigen gene located on chromosome 6. It is a part of the major histocompatibility complex (MHC) family, which helps the immune system recognize and respond to foreign substances. HLA-DRB5 is involved in…

The HLA-G Gene

HLA-G is a major histocompatibility complex (MHC) gene located on chromosome 6. The gene is a member of the HLA-A, -B, -C, -E, -F, and -G family of molecules, which are involved in the regulation of the immune system and other cellular functions.…

The HLA-DQB1 Gene

The HLA-DQB1 gene is an important component of the human leukocyte antigen (HLA) system, a group of genes that regulate the immune system. It is located on chromosome 6 in humans and encodes a class II major histocompatibility complex (MHC)…

The HLA-DQA1 Gene

The HLA-DQA1 gene is a member of the HLA gene family, which is located on the short arm of chromosome 6. The gene encodes proteins that are involved in the immune response and are part of the major histocompatibility complex (MHC). HLA-DQA1…

The HLA-DPB1 Gene

The HLA-DPB1 gene is a gene located on the short arm of the sixth chromosome (6p21.3) and is part of the human leukocyte antigen (HLA) major histocompatibility complex (MHC) locus. The HLA-DPB1 gene is important for the immune system as it is…

The HLA-DPA1 Gene

The HLA-DPA1 gene belongs to the human leukocyte antigen (HLA) family and is located on chromosome 6. It plays a key role in the immune system by helping the body to recognize and respond to foreign antigens. The gene provides instructions for…

The HLA-DRB4 Gene

The HLA-DRB4 gene is a member of the human leukocyte antigen (HLA) family, which is responsible for coding proteins that help the body’s immune system recognize and fight off foreign substances, such as viruses and bacteria. It is located…

The HLA-DRB3 Gene

HLA-DRB3 is a human leukocyte antigen (HLA) gene located on chromosome 6. It codes for a polymorphic cell surface glycoprotein known as the DRB3 molecule. This molecule is a member of the MHC class II family of immune-related proteins and is…

The HLA-DRB1 Gene

The HLA-DRB1 gene is a major histocompatibility complex (MHC) gene located on chromosome 6 in humans. It is a polymorphic gene, meaning that it has many different forms that vary from person to person. The HLA-DRB1 gene encodes for the HLA-DRB1…

The HLA-C Gene

The HLA-C gene is a major histocompatibility complex (MHC) class I gene located on chromosome 6 in humans. It is a member of the MHC Class I family of genes, which are responsible for the recognition and presentation of antigens to the immune…

Understanding How To Best Utilize HLA Typing

HLA typing is a laboratory test used to determine the type of human leukocyte antigen (HLA) that an individual has. HLA are proteins found on the surface of white blood cells, and they play an important role in how our immune system recognizes…

The HLA-B Gene

The human leukocyte antigen (HLA) system is a group of genes located on chromosome 6 that play a crucial role in the immune system. The HLA-B gene is one of the many genes that make up the HLA system, and it is responsible for encoding a protein…

The HLA-A Gene

The human leukocyte antigen (HLA) system is a critical component of the immune system and an essential subject of medical research. The major histocompatibility complex (MHC) is an integral part of the HLA system, and the HLA-A gene is a key…

HLA Typing and HLA Genes in Research: A Primer

Immunology is the study of the immune system, which includes both innate and adaptive immunity. This includes antibodies, specialized proteins that recognize foreign invaders such as bacteria or viruses; T cells, specialized white blood cells…

Nanopore Long-Reads Coming to HLA

GenDx announced NGS-Turbo, a long-read HLA sequencing product for Nanopore instruments. Although we will have to see the actual protocol in practice, HLA sequencing with Nanopore long-reads should offer significant benefits in relation to short-read…

Novel HLA Allele Identified

In May, 2020, we reported on the likely discovery of a novel HLA-B allele (https://bit.ly/3TsmmtY). At that time, we performed HLA typing and sequence alignments against the then current version of the IMGT/HLA database, namely, v.3.38.0. The…

Illumina Announces Long Reads

Illumina recently announced the upcoming availability of long-read technology at the 40th Annual J.P. Morgan Healthcare Conference, in a press release and on Illumina's Genomics Research Hub.  The new long-read sequencing assay is code-named…

On an HLA Null Allele Case Study

A recent case study report describes the discovery of a novel HLA null allele and its effect on protein synthesis and gene expression (Rozar, 2021).  We occasionally deliver HLA reports that include null alleles.  This case study highlights…