On an HLA Null Allele Case Study

A recent case study report describes the discovery of a novel HLA null allele and its effect on protein synthesis and gene expression (Rozar, 2021).  We occasionally deliver HLA reports that include null alleles.  This case study highlights…
hla imgt database

How Did We Discover a Novel HLA Allele?

Intro One of the pleasures of owning a genomics company is assisting client researchers with new discoveries.  Recently, one of our clients completed an 11-loci, 4-field HLA typing project for a clinical trial project.  Using Illumina Next…
SARS-COV2 spike protein

HLA Susceptibility in SARS-CoV-2

Intro Nguyen et al. recently published a paper "Human leukocyte antigen susceptibility map for SARS-CoV-2" in the Journal of Virology  Using in-silico methods, they assessed the binding affinities of MHC Class I alleles (HLA-A, HLA-B,…
Multiplexed samples reduces cost

Cost Savings with Multiplex Samples

Multiplex Sequencing Multiplexing is a method of combining two or more samples in a single sequencing run.  Multiplexing can increase the throughput of sequencing runs and save money at the same time. Conceptually, multiplexing is a fairly…

Gene Panel Design: ACMG Standards

The Paper Bean et al. recently published a report "Diagnostic gene sequencing panels: from design to report - a technical standard of the American College of Medical Genetics and Genomics (ACMG)" that provides technical standards for the…
hla typing

The Cost of HLA Typing

At The Sequencing Center, one of the main services that we provide to pharmaceutical, academic, and clinical researchers is HLA Typing. HLA Typing (human leukocyte antigen) is most commonly leveraged for matching patients and donors for bone…

Bacteriophage DNA Extraction Protocol

We routinely perform bacteriophage whole genome sequencing.  However, we do not currently offer phage DNA extraction services.  Instead, researchers perform phage DNA extraction at their own facilities and then ship purified gDNA to our sequencing…
The Ultimate Guide to Genome Sequencing
Genome Expression Sequencing

The Influence of Genetics on Clinical Research

Like any new technology adoption curve, genome sequencing has gone through the typical hype cycle. We start to leverage a new technology and it becomes massively hyped as the thing that will "change everything" only to realize that we don't…
The future of genomics in the clinical market
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Seqing Knowledge Ep.2 – The Future of Genomics in the Clinical Market

Deidre: Welcome to Seqing Knowledge a genomics podcast from The Sequencing Center. I’m your host Deidre Casey, here at The Sequencing Center lab in Fort Collins, Colorado. Each week we'll take a look at genomics-related topics from current…
press release image

Global HLA Typing Market Study Includes The Sequencing Center as a Top Vendor

As the global HLA Typing market continues to increase in demand, the number of new commercial vendors focusing on HLA Typing has stayed fairly flat relative to growth. In a new market research study conducted by Data Bridge Market Research,…
clinical diagnostics

Increasing Access to Genome Sequencing for Clinical Diagnostics

As genome sequencing continues to decrease in price and increase in demand, the desire for many clinical organizations to leverage genome sequencing as a clinical diagnostic means continues to get traction. In a recent change, the California…
Seqing Knowledge Episode 1
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Seqing Knowledge Ep.1 – What Kind of Sequencing Do I Need?

  Welcome to the very first podcast of Seqing Knowledge, a genomics podcast from The Sequencing Center. Our goal for this show is to provide our listeners with quick episodes centered around genome sequencing. These episodes will…
genome vs exome

Genome, Exome… What’s the Difference?

Genome sequencing is all over the news lately, especially with commercial companies offering sequencing to explore a customer's ethnic background, recommended diets and fitness plans, and reveal what kinds of diseases they might potentially…
cancer

Genome Sequencing and the End of Cancer

Modern genomics and biotechnology have blown open doors for research on many diseases once considered a guaranteed death sentence for those who were diagnosed with them. Years ago, the only treatments for a cancerous tumor growth may have been…
cardiovascular sequencing

Getting to the Heart of the Problem with Cardiovascular Sequencing

It’s American Heart Month and while heart disease maintains its reign as the single leading cause of death among both men and women in the US, there is ongoing research to help people live longer and healthier lives. From a genetic standpoint,…
HLA typing

Find Your Perfect Match: Using HLA Typing For Successful Organ Transplants

Within clinical environments, making decisions based on precise and comprehensive data is paramount in practicing high-quality medicine. One of the more complex clinical procedures involves organ transplants. Organ transplant surgery, a high-risk…
genetics and weight loss

Weighing in on Genetics and Weight Loss

It’s that time of year again when every local gym fills with hundreds of new members, resolute that this is the year they finally follow through on their weight loss goals. Getting healthy is arguably the most common New Year’s resolution,…
How to submit a sample for genome sequencing

How to Submit a Sample for Genome Sequencing

At The Sequencing Center, we receive hundreds of samples every month, and while most of the samples are primed and ready for sequencing, it’s easy for our clients to miss some key preparation steps. In order to get the best results from your…
the genome sequencing process
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The Genome Sequencing Process

The process of sequencing a genetic sample can often feel like a confusing and fragmented process, with each individual step being performed by different vendors before finally ending up with a sequenced genome. In fact, it was our frustration…