The HLA-DPB1 Gene

The HLA-DPB1 gene is a gene located on the short arm of the sixth chromosome (6p21.3) and is part of the human leukocyte antigen (HLA) major histocompatibility complex (MHC) locus. The HLA-DPB1 gene is important for the immune system as it is…

The HLA-DPA1 Gene

The HLA-DPA1 gene belongs to the human leukocyte antigen (HLA) family and is located on chromosome 6. It plays a key role in the immune system by helping the body to recognize and respond to foreign antigens. The gene provides instructions for…

The HLA-DRB4 Gene

The HLA-DRB4 gene is a member of the human leukocyte antigen (HLA) family, which is responsible for coding proteins that help the body’s immune system recognize and fight off foreign substances, such as viruses and bacteria. The HLA-DRB4 gene,…

The HLA-DRB3 Gene

HLA-DRB3 is a human leukocyte antigen (HLA) gene located on chromosome 6. It codes for a polymorphic cell surface glycoprotein known as the DRB3 molecule. This molecule is a member of the MHC class II family of immune-related proteins and is…

The HLA-DRB1 Gene

The HLA-DRB1 gene is a major histocompatibility complex (MHC) gene located on human chromosome 6. It is a polymorphic gene, meaning that it has many different forms that vary from person to person. The HLA-DRB1 gene encodes for the HLA-DRB1…

The HLA-C Gene

The HLA-C gene is a major histocompatibility complex (MHC) class I gene located on human chromosome 6. It is a member of the MHC Class I family of genes, which are responsible for the recognition and presentation of antigens to the immune system.…

Understand How To Best Utilize HLA Typing

HLA typing is a laboratory test used to determine the type of human leukocyte antigen (HLA) that an individual has. HLA are proteins found on the surface of white blood cells, and they play an important role in how our immune system recognizes…

The HLA-B Gene

The human leukocyte antigen (HLA) system is a group of genes located on chromosome 6 that play a crucial role in the immune system. The HLA-B gene is one of the many genes that make up the HLA system, and it is responsible for encoding a protein…

The HLA-A Gene

The human leukocyte antigen (HLA) system is a critical component of the immune system and an essential subject of medical research. The major histocompatibility complex (MHC) is an integral part of the HLA system, and the HLA-A gene is a key…

HLA Typing and HLA Genes in Research: A Primer

Immunology is the study of the immune system, which includes both innate and adaptive immunity. This includes antibodies, specialized proteins that recognize foreign invaders such as bacteria or viruses; T cells, specialized white blood cells…

Nanopore Long-Reads Coming to HLA

GenDx announced NGS-Turbo, a long-read HLA sequencing product for Nanopore instruments. Although we will have to see the actual protocol in practice, HLA sequencing with Nanopore long-reads should offer significant benefits in relation to short-read…

Novel HLA Allele Identified

In May, 2020, we reported on the likely discovery of a novel HLA-B allele (https://bit.ly/3TsmmtY). At that time, we performed HLA typing and sequence alignments against the then current version of the IMGT/HLA database, namely, v.3.38.0. The…

Illumina Announces Long Reads

Illumina recently announced the upcoming availability of long-read technology at the 40th Annual J.P. Morgan Healthcare Conference, in a press release and on Illumina's Genomics Research Hub.  The new long-read sequencing assay is code-named…

On an HLA Null Allele Case Study

A recent case study report describes the discovery of a novel HLA null allele and its effect on protein synthesis and gene expression (Rozar, 2021).  We occasionally deliver HLA reports that include null alleles.  This case study highlights…

Celebrating 5 Years of Sequencing

We are celebrating 5 years in business!  We are so grateful to our clients worldwide who have helped us build our business and successfully hit the 5-year mark.  Without your continued business, it would not have been possible to make it this…

The Sequencing Center Now Offers Long-Read Sequencing Services

FOR IMMEDIATE RELEASE Fort Collins, Colorado, 10/12/2020 - The Sequencing Center, a genome sequencing service provider for biological and clinical research, announced today that it will offer long-read sequencing services to supplement its…
hla imgt database

How Did We Discover a Novel HLA Allele?

Introduction One of the pleasures of owning a genomics company is assisting client researchers with new discoveries.  Recently, one of our clients completed an 11-loci, 4-field HLA typing project for a clinical trial project.  Using Illumina…
SARS-COV2 spike protein

HLA Susceptibility in SARS-CoV-2

Intro Nguyen et al. recently published a paper "Human leukocyte antigen susceptibili8ty map for SARS-CoV-2" in the Journal of Virology  Using in-silico methods, they assessed the binding affinities of MHC Class I alleles (HLA-A, HLA-B,…
Multiplexed samples reduces cost

Cost Savings with Multiplex Samples

Multiplex Sequencing Multiplexing is a method of combining two or more samples (pooling samples) in a single sequencing run.  Multiplexing can increase the throughput of sequencing runs and save money at the same time. Conceptually, multiplexing…
hla typing

The Cost of HLA Typing

At The Sequencing Center, one of the main services that we provide to pharmaceutical, academic, and clinical researchers is HLA Typing. HLA Typing (human leukocyte antigen) is most commonly leveraged for matching patients and donors for bone…