HLA Typing & Testing Solution
ExactHLA™ is a unique, end-to-end genome sequencing pipeline designed for clinical researchers seeking affordable and accurate HLA typing. Using ExactHLA™, clinical researchers gain a high-resolution view of 11 HLA loci with comprehensive data analysis, providing accurate results and allele discovery. At costs starting as little as $250/sample, clinical researchers now have an affordable solution with a rapid turnaround time.
Rapid Solution for Clinical Research
Get fast HLA Typing gene sequencing with high-resolution data for an affordable price. Our all-inclusive clinical research solution provides everything, from DNA extraction to bioinformatics. Clinical researchers simply send samples in and receive insights back.
High-Resolution Results
Take the guesswork out of the equation with our HLA typing gene sequencing panel. Our panel targets 11 HLA loci at high resolution, including Class I and Class II HLA genes.
Each HLA typing sequencing we perform guarantees a minimum 200-300x coverage on each sample. This data is delivered with a comprehensive bioinformatics analysis that generates insights on alleles and provides actionable data for researchers to leverage in their clinical research.
Targeted Loci
| HLA-A | HLA-B | HLA-C | HLA-DRB1/3/4/5 |
| HLA-DQB1 | HLA-DPB1 | HLA-DQA1 | HLA-DPA1 |
Looking for a targeted loci subset? Let’s get in touch to discuss your options.
Applications of HLA Typing
HLA type sequencing is used to determine the antigens present in an individual human’s immune system, making it useful in a variety of circumstances ranging from organ donation to studying celiac disease.
Our HLA clients commonly use HLA typing to:
- Determine organ donation compatibility
- Cancer research
- Autoimmune disorder research for arthritis, celiacs disease, lupus, and type-1 diabetes
- Infectious disease research
- Genetic matchmaking research
HLA Typing Process
- Sample Prep: Raw human DNA samples are checked in with optional in-house DNA extraction
- Library preparation: DNA is amplified and tagged with florescent-tagged nucleotides in a flow cell.
- Quality Control: DNA is run several times through a Qubit Fluorometer as a control checkpoint to confirm the sequencing quality.
- Bacterial Sequencing: The florescent-tagged HLA genes are then sequenced in our Illumina MiniSeq machine, where they are imaged and recorded.
- Bioinformatics: The HLA type sequence and raw data are exported and stored in our secure cloud-based servers for easy access.
For more information check our article on our genome sequencing process.
HLA Typing Deliverables
Every project we run includes all the raw data, FASTQ (aligned genomes), and variant analysis (typically an .xlsx file showing the SNPs). It’s in this way we are able to provide our clients with the data they need as well as transparency in tracking quality control throughout the process.
All of the data is stored on a secure cloud server so our clients can safely download all bioinformatics without it getting lost in email attachments or misplaced USB drives.
Contact Us for a Quote
Our HLA experts are here to answer any questions you have about genome sequencing and provide solutions to your research challenges. Contact us to explore how we can help.
(877) 425-2235
(970) 682-1288 (Direct to Lab)