HLA Typing Services
11-loci & 4-field resolution
HLA Typing has never been easier
Free DNA Extraction
Skip the hassle in your lab.
We extract high quality DNA for you.
Fast Turnaround Time
Get results in days, not months
*based on project size
Actionable Reports
Get standardized HLA reports
for your organization
Whole gene coverage for
Class I HLA alleles
HLA-A
HLA-B
HLA-C
HLA-G
HLA-E (contact us)
HLA-F (contact us)
Extensive coverage for
Class II HLA alleles
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRB1
HLA-DRB3
HLA-DRB4
HLA-DRB5
Don’t need all 11-loci?
We can sequence any subset or combination of loci
Major Histocompatibility Complex (MHC) &
Human Leukocyte Antigen (HLA) Region
The MHC/HLA region is a gene cluster located on human Chromosome 6. It encodes for proteins involved in the immune system’s recognition of self and non-self. And it encodes the presentation of antigens to T-cells. These proteins play an essential role in the body’s ability to recognize and respond to a wide range of pathogens and foreign cells.
The MHC/HLA is divided into two regions:
Class I MHC/HLA region encodes for proteins expressed on the surface of most nucleated cells.
Class II MHC/HLA region encodes for proteins expressed on the surface of antigen-presenting cells.
The MHC/HLA genes are highly polymorphic, the most polymorphic region in the human genome, with a vast number of different alleles that vary significantly between individuals and populations.
Matching the MHC/HLA types of donors and recipients is critical to prevent graft rejection and other complications during transplantation and transfusion procedures.
HLA typing is a critical component of both clinical and research settings. It enables the accurate identification of HLA alleles and the prediction of immune responses. Understanding the MHC/HLA systems’ complexity and diversity is essential for healthcare professionals, researchers, and patients to comprehend the mechanisms underlying immune recognition and response.
Disease States
The remarkable HLA region on human Chromosome 6 is associated with a wide array of diseases:
Addison’s disease
Ankylosing spondylitis
Autoimmune diseases
Celiac disease
Graves’ disease
Hashimoto’s thyroiditis
Multiple sclerosis
Myasthenia gravis
Rheumatoid arthritis
Systemic lupus erythematosus
Type 1 diabetes
And many more
HLA Next Generation Sequencing
We use Next Generation Sequencing (NGS) technology from Illumina and Nanopore for HLA Typing. Illumina offers short-read sequencing methods and Nanopore will soon offer long-read sequencing methods for HLA Typing. Both methods yield 4-field resolution by default.
Illumina short-read sequencing is a widely used NGS platform for HLA Typing. This technology involves the fragmentation of DNA into small fragments (reads), followed by PCR amplification, sequencing and alignment of the reads to the IMGT/HLA database. We deliver the Illumina HLA Typing results in standardized reports.
Nanopore long-read sequencing is another NGS platform that will soon be available for HLA Typing. Nanopore technology uses single-molecule sequencing, generating long reads up to several hundred kilobases. The Nanopore workflow includes the preparation of long-read DNA libraries, followed by sequencing on Nanopore MinION or Flongle platforms. We will also deliver Nanopore HLA Typing results in standardized reports.
Top research institutions trust us
“Many thanks for the quick results. The files are so easy to look at and have very thorough data readout.”
– Michele, A2 Biotherapeutics