Cure Diseases with HLA Sequencing

High-quality HLA Typing for 11 loci and 4-field resolution

HLA Gene Coverage

Our gene panel covers 11 HLA loci at 4-field resolution.
Coverage includes all relevant exons, introns, 5′-UTR’s and 3′-UTR’s

Whole gene coverage for Class I HLA genes

HLA-A
HLA-B
HLA-C

Extensive coverage for Class II HLA genes

HLA-DPA1 / DPB1
HLA-DQA1 / DQB1
HLA-DRB1/ 3/ 4/ 5

HLA-E (coming soon)
HLA-G (optional)

Don’t need all 11 loci?

We can sequence any subset or combination of loci you require.

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HLA Reports

HLA Typing reports include

4-field resolution for each allele

CWD status

HLA typing ambiguities

P-group and G-group typing results

Metadata

All projects include FASTQ data files

Download Sample HLA Report

HLA sequencing has never been easier

Free DNA Extraction

Skip the hassle in your lab. We extract high quality DNA for your run.

Fast Turnaround Time

Get results in days, not months

*based on project size

Actionable Reports

Get the results you need for breakthrough research

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Major Histocompatibility Complex (MHC)

The Major Histocompatibility Complex (MHC) is a set of highly polymorphic genes in the innate and adaptive immune systems. Human Leucocyte Antigen (HLA) proteins are encoded by MHC genes.

The HLA complex is divisible into Class I and Class II alleles based on the structure and function of the encoded proteins. The extreme diversity of Class I and II alleles is responsible for their wide-ranging importance in disease states and immunity.

HLA Typing determines the compatibility of donors and recipients for organ and tissue transplantation. Mismatched donor and recipient organs or tissues can lead to their rejection by the immune system.

HLA Typing also determines one’s susceptibility to autoimmune diseases and reactions to vaccines and immunization.

MHC Related Disease States and Immunity

Innate immunity

Adaptive immunity

Antigen presentation

Inflammation regulation

Autoimmune diseases

Type 1 diabetes

Multiple sclerosis

Rheumatoid arthritis

Graves’ disease

Ankylosing spondylitis

Systemic lupus erythematosus

Hashimoto’s thyroiditis

Myasthenia Gravis

Addison’s disease

Celiac disease

Many additional diseases

Top research institutions trust us

“Many thanks for the quick results. The files are so easy to look at and have very thorough data readout.”

– Michele, A2 Biotherapeutics

About

The Sequencing Center is a USA-owned and operated next-generation genome sequencing company offering affordable genome sequencing and bioinformatics for research, pharmaceutical, and clinical organizations. Our services are designed for organizations performing research on bacterial, viral, and human-oriented research. Among these services, our facility offers targeted sequencing methods for research fields including inherited diseases, oncology, neurodegenerative diseases, antibiotic-resistant gene analysis, and biomarker discovery for drug development optimization.