The standardized HLA gene and allele nomenclature is managed by the WHO Nomenclature Committee for Factors of the HLA System. A high-level summary of their nomenclature system is reproduced here for easy reference. A thorough and detailed review of the HLA naming schema is available online.
Fig. 1
Fig. 1 shows the standard naming convention for HLA alleles. It includes the HLA gene name, the HLA allele group for a specific gene, a specific non-synonymous allele (i.e. one that changes a protein amino acid sequence), a specific synonymous allele (i.e. one that does not change a protein amino acid sequence), non-CDS (coding sequence) alleles (i.e. introns, 5′-UTR’s, 3′-UTR’s, etc.) and suffixes that denote protein expression level.
HLA Field | Definition |
---|---|
HLA | The HLA region and prefix for an HLA gene |
HLA-DRB1 | A particular HLA locus i.e. DRB1 |
HLA-DRB1*13 | A group of alleles that encode the DR13 antigen or sequence homology to other DRB1*13 alleles |
HLA-DRB1*13:01 | A specific HLA allele |
HLA-DRB1*13:01:02 | An allele that differs by a synonymous mutation from DRB1*13:01:01 |
HLA-DRB1*13:01:01:02 | An allele that contains a mutation outside the coding region from DRB1*13:01:01:01 |
HLA-A*24:09N | A 'Null' allele. An allele that is not expressed |
HLA-A*30:14L | An allele that encodes a protein with significantly reduced or 'Low' cell surface expression |
HLA-A*24:02:01:02L | An allele that encodes a protein with significantly reduced or 'Low' cell surface expression, where the mutation is found outside the coding region |
HLA-B*44:02:01:02S | An allele that encodes a protein which is expressed as a 'Secreted' molecule only |
HLA-A*32:11Q | An allele which has a mutation that has previously been shown to have a significant effect on cell surface expression, but where this has not been confirmed and its expression remains 'Questionable' |
Table 1
Table 1 shows the definitions of HLA alleles at various levels of resolution. The HLA nomenclature described in Fig. 1 and Table 1 is reflected in the HLA reports that we deliver for each HLA sample and HLA sequencing run. If you’re in receipt of these reports you may want to refer to the HLA nomenclature described here.
The Sequencing Center is one of the leading service providers for HLA Typing and Whole Genome Sequencing (WGS) in the USA. Offering affordable, high-coverage HLA typing results with 4-field resolution and microbial scale WGS, we provide clients with exceptional services, including DNA extraction, library prep, sequencing and bioinformatics. We work with leading research organizations world-wide in various fields including immunology, oncology, transplantation, inherited diseases, neurodegenerative diseases, and drug discovery and development.
1020 Luke Street
Suite D
Fort Collins, CO 80524
U.S.A.
(877) 425-2235
(970) 682-1288 (Direct to lab)
info@thesequencingcenter.com
This site uses cookies. By continuing to browse the site, you are agreeing to our use of cookies.
OKLearn moreWe may request cookies to be set on your device. We use cookies to let us know when you visit our websites, how you interact with us, to enrich your user experience, and to customize your relationship with our website.
Click on the different category headings to find out more. You can also change some of your preferences. Note that blocking some types of cookies may impact your experience on our websites and the services we are able to offer.
These cookies are strictly necessary to provide you with services available through our website and to use some of its features.
Because these cookies are strictly necessary to deliver the website, refusing them will have impact how our site functions. You always can block or delete cookies by changing your browser settings and force blocking all cookies on this website. But this will always prompt you to accept/refuse cookies when revisiting our site.
We fully respect if you want to refuse cookies but to avoid asking you again and again kindly allow us to store a cookie for that. You are free to opt out any time or opt in for other cookies to get a better experience. If you refuse cookies we will remove all set cookies in our domain.
We provide you with a list of stored cookies on your computer in our domain so you can check what we stored. Due to security reasons we are not able to show or modify cookies from other domains. You can check these in your browser security settings.
These cookies collect information that is used either in aggregate form to help us understand how our website is being used or how effective our marketing campaigns are, or to help us customize our website and application for you in order to enhance your experience.
If you do not want that we track your visit to our site you can disable tracking in your browser here:
We also use different external services like Google Webfonts, Google Maps, and external Video providers. Since these providers may collect personal data like your IP address we allow you to block them here. Please be aware that this might heavily reduce the functionality and appearance of our site. Changes will take effect once you reload the page.
Google Webfont Settings:
Google Map Settings:
Google reCaptcha Settings:
Vimeo and Youtube video embeds:
The following cookies are also needed - You can choose if you want to allow them:
You can read about our cookies and privacy settings in detail on our Privacy Policy Page.
Privacy Policy