What diseases are associated with HLA alleles?

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The set of HLA alleles are associated with a wide variety of disease states.  Some of the more common HLA – disease associations are listed here.

 

What diseases are associated with HLA-A?

The diseases associated with HLA-A include: ankylosing spondylitis, celiac disease, type 1 diabetes, Graves’ disease, rheumatoid arthritis, psoriasis, inflammatory bowel disease, and multiple sclerosis.

What diseases are associated with HLA-B?
The diseases associated with HLA–B include ankylosing spondylitis, rheumatoid arthritis, psoriasis, multiple sclerosis, type 1 diabetes, Crohn‘s disease, celiac disease, systemic lupus erythematosus, and narcolepsy.

What diseases are associated with HLA-C?
The diseases associated with HLA–C include psoriasis, ankylosing spondylitis, Behcet‘s disease, type 1 diabetes mellitus, multiple sclerosis, rheumatoid arthritis, ulcerative colitis, and Crohn‘s disease.

What diseases are associated with HLA-DPA1?
The diseases associated with HLA-DPA1 include celiac disease, type 1 diabetes, Graves’ disease, autoimmune hepatitis, rheumatoid arthritis, and ankylosing spondylitis.

What diseases are associated with HLA-DPB1?
HLA–DPB1 is associated with a variety of autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, psoriasis, multiple sclerosis, and systemic lupus erythematosus.

What diseases are associated with HLA-DQA1?
HLA-DQA1 is associated with a variety of autoimmune diseases, including type 1 diabetes, celiac disease, Graves’ disease, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis.

What diseases are associated with HLA-DQB1?
The diseases associated with HLA–DQB1 include type 1 diabetes, celiac disease, Graves‘ disease, rheumatoid arthritis, ankylosing spondylitis, and inflammatory bowel disease.

What diseases are associated with HLA-DRB1?
HLA–DRB1 is associated with various autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren‘s syndrome, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel diseases, type 1 diabetes, and multiple sclerosis.

What diseases are associated with HLA-DRB3?
HLA–DRB3 is associated with a variety of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, juvenile idiopathic arthritis, Sjogren‘s syndrome, and multiple sclerosis. It is also associated with a predisposition to certain types of infections, such as Mycobacterium tuberculosis.

What diseases are associated with HLA-DRB4?
The diseases associated with HLA–DRB4 include sarcoidosis, Sjogren‘s syndrome, idiopathic thrombocytopenic purpura, systemic lupus erythematosus, rheumatoid arthritis, Graves‘ disease, Hashimoto‘s thyroiditis, type 1 diabetes mellitus, Addison‘s disease, ankylosing spondylitis, psoriasis, vitiligo, and multiple sclerosis.

What diseases are associated with HLA-DRB5?
HLA–DRB5 is associated with a number of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren‘s syndrome, juvenile idiopathic arthritis, and autoimmune hepatitis. It has also been associated with an increased risk for Behcet‘s disease, type 1 diabetes, and multiple sclerosis.

What diseases are associated with HLA-G?
HLA–G is associated with a number of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus (SLE), Graves‘ disease, multiple sclerosis, and inflammatory bowel disease.

To perform a deep dive into these HLA alleles check out GeneCards and MalaCards.