Human blood consists of leukocytes, thrombocytes and erythrocytes. Only leukocytes contain a cell nucleus. Thrombocytes and erythrocytes do not contain a cell nucleus. Thus, leukocytes are the most important element when estimating the amount of DNA in human blood.
The blood of a healthy individual usually contains 425 – 750 leucocyte cells per milliliter of blood. This means that the DNA content can vary between 30 – 40 µg/mL of blood depending on the donor.
Please note that the number of leukocytes per millilitre of blood can vary considerably from 225 during immunosuppression, to 4,250 during inflammation and up to 55,000 during leukemia.
The standard mass formula for dsDNA is:
mass of dsDNA (g) = moles of dsDNA (mol) x ( (length of dsDNA (bp) x 617.96 g/mol/bp) + 36.04 g/mol)
mass of dsDNA = moles dsDNA (mol) x molecular weight of dsDNA
molecular weight of dsDNA = (number of base pairs of dsDNA x average molecular weight of a base pair) + 36.04 g/mol
average molecular weight of a base pair = 617.96 g/mol, excluding the water molecule removed during polymerization
the 36.04 g/mol accounts for the 2 -OH and 2 -H added back to the ends
https://thesequencingcenter.com/wp-content/uploads/2019/01/TSC_wide_logo_blue-e1546560904499.png00Richard Caseyhttps://thesequencingcenter.com/wp-content/uploads/2019/01/TSC_wide_logo_blue-e1546560904499.pngRichard Casey2020-10-26 14:46:322020-12-20 14:35:00How much DNA is contained in human blood cells?
We may request cookies to be set on your device. We use cookies to let us know when you visit our websites, how you interact with us, to enrich your user experience, and to customize your relationship with our website.
Click on the different category headings to find out more. You can also change some of your preferences. Note that blocking some types of cookies may impact your experience on our websites and the services we are able to offer.
Essential Website Cookies
These cookies are strictly necessary to provide you with services available through our website and to use some of its features.
Because these cookies are strictly necessary to deliver the website, refuseing them will have impact how our site functions. You always can block or delete cookies by changing your browser settings and force blocking all cookies on this website. But this will always prompt you to accept/refuse cookies when revisiting our site.
We fully respect if you want to refuse cookies but to avoid asking you again and again kindly allow us to store a cookie for that. You are free to opt out any time or opt in for other cookies to get a better experience. If you refuse cookies we will remove all set cookies in our domain.
We provide you with a list of stored cookies on your computer in our domain so you can check what we stored. Due to security reasons we are not able to show or modify cookies from other domains. You can check these in your browser security settings.
Other external services
We also use different external services like Google Webfonts, Google Maps, and external Video providers. Since these providers may collect personal data like your IP address we allow you to block them here. Please be aware that this might heavily reduce the functionality and appearance of our site. Changes will take effect once you reload the page.
Google Webfont Settings:
Google Map Settings:
Google reCaptcha Settings:
Vimeo and Youtube video embeds:
Privacy Policy
You can read about our cookies and privacy settings in detail on our Privacy Policy Page.