Human blood consists of leukocytes, thrombocytes, and erythrocytes. Only leukocytes contain a cell nucleus. Thrombocytes and erythrocytes do not contain a cell nucleus. Thus, leukocytes are the most important element when estimating the amount of DNA in human blood.
The blood of a healthy individual usually contains 425 – 750 leucocyte cells per milliliter of blood. This means that the DNA content can vary between 30 – 40 µg/mL of blood depending on the donor.
Please note that the number of leukocytes per milliliter of blood can vary considerably from 225 during immunosuppression, to 4,250 during inflammation and up to 55,000 during leukemia.
The standard mass formula for dsDNA is:
mass of dsDNA (g) = moles of dsDNA (mol) x ( (length of dsDNA (bp) x 617.96 g/mol/bp) + 36.04 g/mol)
The Sequencing Center is one of the leading service providers for HLA Typing and Whole Genome Sequencing (WGS) in the USA. Offering affordable, high-coverage HLA typing results with 4-field resolution and microbial scale WGS, we provide clients with exceptional services, including DNA extraction, library prep, sequencing and bioinformatics. We work with leading research organizations world-wide in various fields including immunology, oncology, transplantation, inherited diseases, neurodegenerative diseases, and drug discovery and development.
1020 Luke Street
Fort Collins, CO 80524
(970) 682-1288 (Direct to lab)
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