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Why does DRB1/3/4/5 show ‘No typing result available’?

We use the GenDx NGSengine application for HLA typing and HLA report generation. The HLA loci DRB3, DRB4 and DRB5 are paralogs of locus DRB1.  Thus, they share a significant fraction of their genetic sequence with DRB1. The NGSengine HLA…

HLA IMGT Database

IMGT Database The IPD-IMGT/HLA database contains genetic sequence and allele data for the human major histocompatibility complex (MHC). This database is foundational for many HLA Typing algorithms and Next-Generation sequencing projects.  It…
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HLA publication list for GenDx

We vet our vendors carefully before using products in our sequencing workflows.  The Sequencing Center uses the GenDx libraries for NGS (Next Generation Sequencing)-based HLA typing.  The combination of substantial immunological research,…
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How to read HLA reports

We deliver detailed HLA reports to clients immediately after their HLA sequencing runs are complete. The reports include information about HLA allele typing calls, allele ambiguities, and relevant metadata. HLA Loci The full set of HLA loci…
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HLA nomenclature

The standardized HLA gene and allele nomenclature is managed by the WHO Nomenclature Committee for Factors of the HLA System.  A high-level summary of their nomenclature system is reproduced here for easy reference.  A thorough and detailed…

How to access your sequencing data

When sequencing runs are finished, we automatically upload FastQ files to a client's Box.com account. These files are typically found in the directory: ClientName-> Reports-> ReportID-> FastQ The FastQ files in this directory…