Getting to the Heart of the Problem with Cardiovascular Sequencing

cardiovascular sequencing

It’s American Heart Month and while heart disease maintains its reign as the single leading cause of death among both men and women in the US, there is ongoing research to help people live longer and healthier lives. From a genetic standpoint, cardiovascular health is affected by a wide variety of different genes. The Illumina TruSight Cardio panels used at The Sequencing Center cover 174 different genes, many of which are important in germline inheritance research. From heart attack and coronary artery disease risk to arrhythmia and heart failure, upwards of 17 different potentials inherited cardiac conditions (ICCs) can be viewed through the scope of genomics. These ICCS can help researchers better understand the pathways through which heart disease manifests.

Discover More with Cardiovascular Sequencing

Much of what our cardiovascular panels cover is used in a research setting, where scientists can look at the genes associated with a heightened risk of heart disease and determine whether the disease is more likely inherited from a patient’s bloodline or is caused by an SNP derived from environmental factors. According to Illumina, upwards of a quarter or more of all sudden cardiac death cases can be attributed to genetic influences. This makes the study of inherited cardiac conditions vital to researchers and physicians alike. One of these inherited traits, the low-density lipoprotein receptor (LDL-R), was first identified in a Nobel Prize-winning study in 1985 by Joseph L. Goldstein and Michael S. Brown. This research exemplifies the kind of important discoveries that can be made by studying the genes associated with heart disease risks.

Early Integration for Better Results

By including genome sequencing earlier in clinical studies, physicians can determine what kind of treatments would be most effective from the start, instead of trying to determine the issues through a process of elimination or symptomatic guesswork. There are many loci associated with heart disease and heart disease risk. It is possible that the combination of the wide-ranging gene locations with associated, unpredictable gene mutations can cause new pathways through which heart disease manifests itself.

Whether it be related to cholesterol, muscle disorder, or the effects of smoking on cardiovascular health, The Sequencing Center is here to open new doors into sequencing as a resource for research. Contact us if you have any questions about how to incorporate next-generation sequencing into your cardiovascular research.

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