3D render of a DNA strandThe Sequencing Center

A Guide to HLA Typing with Nanopore Long Read Sequencing

The human leukocyte antigen (HLA) complex plays a critical role in the immune system's ability to distinguish between self and non-self. Accurate HLA typing is essential for many applications, including organ and stem cell transplantation, disease…
HLA typing for drug discoveryThe Sequencing Center

HLA Typing and PyMol Modeling: Revolutionizing Drug Development through Immunogenetics

Introduction to HLA Typing for Drug Development The human leukocyte antigen (HLA) system plays a crucial role in immune response and drug hypersensitivity reactions. HLA molecules present peptides to T cells to elicit immune responses, but…
Scientific drug discoveryThe Sequencing Center

How HLA Typing informs Drug Development

Understanding HLA Binding Specificity to Inform Drug Development Human leukocyte antigen (HLA) molecules play a critical role in immune responses by presenting peptides to T cells. HLA genes are highly polymorphic, with thousands of HLA alleles…
Scientist comparing genomic dataThe Sequencing Center

HLA Typing and Gene Expression Profiling

Introduction Human leukocyte antigen (HLA) typing has become an invaluable tool for understanding immune responses and investigating protein pathways associated with HLA genes. High-resolution HLA typing provides precise characterization of…
3D render of a DNA strandThe Sequencing Center

The Role of HLA Typing in Understanding the HLA-A*24:02:01:01 Allele

Human leukocyte antigen (HLA) typing is a critical process in immunogenetics, enabling the identification of specific alleles within the HLA system. This system, integral to the adaptive immune response, is highly polymorphic, with numerous…
3D render of a long-read dna strandThe Sequencing Center

Illumina vs Nanopore Sequencing: A Technical Comparison for HLA Typing

Human leukocyte antigen (HLA) typing is essential for bone marrow and organ transplantation. Accurate HLA typing at high resolution is critical to ensure donor-recipient matching and prevent graft rejection. Two major sequencing technologies…
Scientist in a research labThe Sequencing Center

Unraveling the Complexities of HLA Mutations and Its Implications in Disease Susceptibility

As research into human leukocyte antigens (HLAs), hugely important molecular markers of the immune response, continues to grow, it consistently unveils a multifaceted array of genetic expressions that contribute to disease susceptibility. HLAs,…
3D render of a DNA strandThe Sequencing Center

Unveiling the Intricacies of HLA Genetic Protein Interactions

The human immune system is delicately complex, constantly modulating responses in real-time in the face of an unending, unseen assault by a myriad of pathogens. Central to this pivotal defense mechanism is the Human Leukocyte Antigen (HLA) system,…
3D render of a DNA strandThe Sequencing Center

Unlocking the Mysteries of Immunity: A Deeper Look into the HLA-A Gene

Introduction Human Leukocyte Antigen-A (HLA-A) plays an instrumental role in the immune system, gaining increasing recognition for its diverse influences on our bodies' defense mechanisms. HLA-A gene, a part of the major histocompatibility…
Artificial intelligence
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Leveraging AI and ML in HLA Typing: A New Frontier in Health Science

Our understanding of human health is constantly evolving, and at the cutting edge of this expansion is the increasingly critical role of Human Leukocyte Antigen (HLA) typing. This method, key in immunogenetic research, involves identifying specific…
HLA-DRB1

HLA Typing the HLA-DRB Allele Paralogues

As we navigate the fascinating world of human genetics, we're consistently astounded by the complexity and diversity of our gene networks. Our journey today brings us to a family of genes that share a remarkable history…
Nanopre long-read sequencing

Harnessing Long-Read Sequencing in HLA Typing

The Human Leukocyte Antigen (HLA) system holds a significant role in the world of genomics, driving research in areas as diverse as organ transplantation, disease association studies, and immune response. HLA Typing, a method used…
MHC Cells

HLA Typing and the Fundamentals of Immunology

The very essence of HLA typing and its integral role in immunology rests in the highly polymorphic nature of the HLA genes. These genes, responsible for encoding MHC proteins, are key orchestrators of our immune response, a dynamic and complex…
HLA NGS

Mastering the Art of HLA Typing

For those who TL;DR, here's a summary.   The paper titled "The changing landscape of HLA typing: Understanding how and when HLA typing data can be used with confidence from bench to bedside" by Lee Ann Baxter-Lowe1…
T-lymphocytes attack a migrating cancer cell.

HLA Typing and Immuno-oncology

Human Leukocyte Antigen (HLA) typing, a cornerstone of immunogenetics, is a sophisticated method used to identify the specific variants of HLA genes in an individual. Given the role of HLA genes in immune regulation and response, HLA typing…
CAR-T Therapy

What is the relationship between CAR-T and HLA Loci?

Chimeric Antigen Receptor T-cell (CAR-T) therapy represents a groundbreaking shift in our approach to treating malignancies, reshaping the landscape of cancer therapy. This revolutionary treatment involves engineering a patient's own T cells…
Disease susceptibility

The Influence of HLA Typing on Disease Susceptibility

The Human Leukocyte Antigen (HLA) system functions as a pivotal player in the architecture of our immune response, playing a key role in the recognition and eradication of foreign pathogens. By studying the variations in HLA types, or HLA typing,…
How do CD8*T cells kill infected cells?

HLA-A*01:01:01:01 Allele and its Impact on the Development of Malignancies

The Human Leukocyte Antigen (HLA) system plays a crucial role in immune recognition and response against pathogens and malignant cells. The HLA-A*01:01:01:01 allele has been linked to an increased risk of developing certain malignancies, such…
HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms

The HLA-A*32:01 Variant: A Focused Exploration for Immunology Experts

The Human Leukocyte Antigen (HLA) system is a cornerstone of the adaptive immune response, consisting of cell surface molecules encoded by the major histocompatibility complex (MHC) genes. The HLA-A gene, a member of the MHC class I family,…
MHC Class I and Class II

A Quick Guide to Human Leukocyte Antigen (HLA) Typing Techniques

Human leukocyte antigens (HLAs) are proteins found on the surface of cells that play a vital role in the immune system. HLA typing is a critical process for determining compatibility between donors and recipients in organ transplantation, hematopoietic…