HLA-DQA1

The HLA-DQA1 Gene

The HLA-DQA1 gene is a member of the HLA gene family, which is located on the short arm of chromosome 6. The gene encodes proteins that are involved in the immune response and are part of the major histocompatibility complex (MHC). HLA-DQA1…
HLA-DPB1

The HLA-DPB1 Gene

The HLA-DPB1 gene is a gene located on the short arm of the sixth chromosome (6p21.3) and is part of the human leukocyte antigen (HLA) major histocompatibility complex (MHC) locus. The HLA-DPB1 gene is important for the immune system as it is…
HLA-DPA1

The HLA-DPA1 Gene

The HLA-DPA1 gene belongs to the human leukocyte antigen (HLA) family and is located on chromosome 6. It plays a key role in the immune system by helping the body to recognize and respond to foreign antigens. The gene provides instructions for…
HLA-DRB4

The HLA-DRB4 Gene

The HLA-DRB4 gene is a member of the human leukocyte antigen (HLA) family, which is responsible for coding proteins that help the body’s immune system recognize and fight off foreign substances, such as viruses and bacteria. The HLA-DRB4 gene,…
HLA-DRB3

The HLA-DRB3 Gene

HLA-DRB3 is a human leukocyte antigen (HLA) gene located on chromosome 6. It codes for a polymorphic cell surface glycoprotein known as the DRB3 molecule. This molecule is a member of the MHC class II family of immune-related proteins and is…
HLA-DRB1

The HLA-DRB1 Gene

The HLA-DRB1 gene is a major histocompatibility complex (MHC) gene located on human chromosome 6. It is a polymorphic gene, meaning that it has many different forms that vary from person to person. The HLA-DRB1 gene encodes for the HLA-DRB1…
HLA-C

The HLA-C Gene

The HLA-C gene is a major histocompatibility complex (MHC) class I gene located on human chromosome 6. It is a member of the MHC Class I family of genes, which are responsible for the recognition and presentation of antigens to the immune system.…
HLA blood sample

Understand How To Best Utilize HLA Typing

HLA typing is a laboratory test used to determine the type of human leukocyte antigen (HLA) that an individual has. HLA are proteins found on the surface of white blood cells, and they play an important role in how our immune system recognizes…
HLA-B

The HLA-B Gene

The human leukocyte antigen (HLA) system is a group of genes located on chromosome 6 that play a crucial role in the immune system. The HLA-B gene is one of the many genes that make up the HLA system, and it is responsible for encoding a protein…
HLA-A

The HLA-A Gene

The human leukocyte antigen (HLA) system is a critical component of the immune system and an essential subject of medical research. The major histocompatibility complex (MHC) is an integral part of the HLA system, and the HLA-A gene is a key…
HLA Genes

HLA Typing and HLA Genes in Research: A Primer

Immunology is the study of the immune system, which includes both innate and adaptive immunity. This includes antibodies, specialized proteins that recognize foreign invaders such as bacteria or viruses; T cells, specialized white blood cells…
GenDX NGS-Turbo with Oxford Nanopore Technologies

Nanopore Long-Reads Coming to HLA

GenDx announced NGS-Turbo, a long-read HLA sequencing product for Nanopore instruments. Although we will have to see the actual protocol in practice, HLA sequencing with Nanopore long-reads should offer significant benefits in relation to short-read…
Novel HLA allele identifiedThe Sequencing Center
,

Novel HLA Allele Identified

In May 2020, we reported on the likely discovery of a novel HLA-B allele, a finding that would later unfold into a captivating tale of scientific collaboration and the importance of data archiving. During our initial analysis, we performed HLA…
Illumina long-reads
,

Illumina Announces Long Reads

Illumina recently announced the upcoming availability of long-read technology at the 40th Annual J.P. Morgan Healthcare Conference, in a press release and on Illumina's Genomics Research Hub.  The new long-read sequencing assay is code-named…
HLA Class I and Class II

On an HLA Null Allele Case Study

A recent case study report describes the discovery of a novel HLA null allele and its effect on protein synthesis and gene expression (Rozar, 2021).  We occasionally deliver HLA reports that include null alleles.  This case study highlights…
hla imgt database
,

How Did We Discover a Novel HLA Allele?

One of the pleasures of owning a genomics company is assisting client researchers with new discoveries.  Recently, one of our clients completed an 11-loci, 4-field HLA typing project for a clinical trial project.  Using Illumina Next Generation…
SARS-COV2 spike protein

HLA Susceptibility in SARS-CoV-2

Nguyen et al. recently published a paper "Human leukocyte antigen susceptibili8ty map for SARS-CoV-2" in the Journal of Virology. Using in-silico methods, they assessed the binding affinities of MHC Class I alleles (HLA-A, HLA-B, HLA-C) with…
Multiplexed samples reduces cost

Cost Savings with Multiplex Samples

Multiplex sequencing, or multiplexing for short, is a method of combining two or more samples (pooling samples) in a single sequencing run. Multiplexing can increase the throughput of sequencing runs and save money at the same time. Conceptually,…
hla typing

The Cost of HLA Typing

At The Sequencing Center, one of the main services that we provide to pharmaceutical, academic, and clinical researchers is HLA Typing. HLA Typing (human leukocyte antigen) is most commonly leveraged for matching patients and donors for bone…

Bacteriophage DNA Extraction Protocol

We routinely perform bacteriophage whole genome sequencing.  However, we do not currently offer phage DNA extraction services.  Instead, researchers perform phage DNA extraction at their own facilities and then ship purified gDNA to our sequencing…