Entries by Ryan Casey

HLA Typing: Disease States Associated with HLA-DRB1/3/4/5 Genes

This blog post presents an overview of the disease states associated with variations in the human leukocyte antigen (HLA) DRB1, DRB3, DRB4, and DRB5 genes. We will discuss the importance of HLA typing in the context of these diseases, the various techniques employed, and the potential impact on diagnosis and treatment. Introduction to HLA-DRB1/3/4/5 Gene […]

HLA Typing: Exploring Disease States Associated with Variants of the HLA-B Gene

Introduction Human Leukocyte Antigen (HLA) typing is an essential tool in understanding genetic susceptibility to diseases, as it identifies specific alleles associated with various disease states. Among the HLA genes, the HLA-B gene has been extensively studied due to its crucial role in immune response and its link to numerous diseases. This whitepaper investigates the […]

Decoding HLA-A: Common Allele Variants and Their Clinical Implications

The Human Leukocyte Antigen (HLA) system, a group of genes within the Major Histocompatibility Complex (MHC), plays a critical role in the immune response. HLA class I molecules, including HLA-A, -B, and -C, are responsible for presenting intracellular peptides to cytotoxic T cells. Given their immunological importance, HLA genes are highly polymorphic, with HLA-A being […]

Collecting and Shipping PBMC and Cell Pellet Samples for HLA Typing

Peripheral blood mononuclear cells (PBMCs) and cell pellets are common sources of DNA for human leukocyte antigen (HLA) typing in immune-related disease research. However, collecting these samples from donors can pose challenges that researchers should be aware of to ensure that the samples are of high quality and produce reliable and valuable data. Additionally, researchers […]

The Benefits of 4-Field Resolution for HLA Typing

Human leukocyte antigen (HLA) typing is an essential component of research into immune-related diseases, including autoimmune disorders and infectious diseases. HLA genes are highly polymorphic, meaning that they come in many different forms, and there are thousands of possible HLA alleles. Researchers often use HLA typing to investigate the genetic factors that influence disease susceptibility […]

Understand How To Best Utilize HLA Typing

HLA typing is a laboratory test used to determine the type of human leukocyte antigen (HLA) that an individual has. HLA are proteins found on the surface of white blood cells, and they play an important role in how our immune system recognizes foreign substances such as bacteria or viruses. Knowing someone’s HLA type can […]

The HLA-B Gene

The human leukocyte antigen (HLA) system is a group of genes located on chromosome 6 that play a crucial role in the immune system. The HLA-B gene is one of the many genes that make up the HLA system, and it is responsible for encoding a protein that helps the immune system to recognize and […]

The HLA-A Gene

The human leukocyte antigen (HLA) system is a critical component of the immune system and an essential subject of medical research. The major histocompatibility complex (MHC) is an integral part of the HLA system, and the HLA-A gene is a key gene within this complex. This gene plays an important role in the body’s ability […]

HLA Typing and HLA Genes in Research: A Primer

Immunology is the study of the immune system, which includes both innate and adaptive immunity. This includes antibodies, specialized proteins that recognize foreign invaders such as bacteria or viruses; T cells, specialized white blood cells which are involved in cell-mediated immunity; and phagocytes (white blood cells) that engulf microbial invaders. Understanding these components of the […]

The Cost of HLA Typing

At The Sequencing Center, one of the main services that we provide to pharmaceutical, academic, and clinical researchers is HLA Typing. HLA Typing (human leukocyte antigen) is most commonly leveraged for matching patients and donors for bone marrow or cord blood transplants. However, it is also used in a lot of immunotherapy research for drug […]

The Influence of Genetics on Clinical Research

Like any new technology adoption curve, genome sequencing has gone through the typical hype cycle. We start to leverage a new technology and it becomes massively hyped as the thing that will “change everything” only to realize that we don’t know what to do with it. We then go into despair because it seemingly hasn’t […]

Increasing Access to Genome Sequencing for Clinical Diagnostics

As genome sequencing continues to decrease in price and increase in demand, the desire for many clinical organizations to leverage genome sequencing as a clinical diagnostic means continues to get traction. In a recent change, the California State Legislature approved a pilot budget and project to research the benefits of leveraging genome sequencing for disease […]

Genome Sequencing Facility Makes Move to Commoditize DNA Extraction By Offering Free DNA Extraction

FOR IMMEDIATE RELEASE Fort Collins, Colorado, 5/17/2018 – The Sequencing Center, a next generation genome sequencing company, made a big move today by announcing free DNA extraction for any genome sequencing project that comes through their facility. The company already offers free basic bioinformatics, which includes alignment and variant analysis, as part of its efforts […]

Why You Need Genome Sequencing in Clinical Research

Clinical research is a tedious process that requires precise data to validate research claims. In its current state, there are many parts of the process that break down for various reasons. Between time constraints, financial resource allocation, data collective practices, material purchasing, cross-team communication, and so much more, there are big hurdles that all lead to […]

Why You Need Genome Sequencing in Clinical Trials

The Challenges of Clinical Trials Working on clinical trials in the pharmaceutical or clinical research field can frequently be a messy process with numerous complications. You can feel blocked and delayed by staggering testing costs and lengthy trial durations. There are, however, many ways to optimize clinical trials through enrollment planning, cost benchmarking, forecasting and […]

Genome Sequencing Facility Promises Highly Affordable Pricing and Scalable Sequencing

FOR IMMEDIATE RELEASE Fort Collins, Colorado, 07/20/2017 –  The Sequencing Center, a next generation genome sequencing company, opened its lab today promising affordable genome sequencing, bioinformatics, and genome data management for research, pharmaceutical, and clinical organizations. The company is offering services for organizations performing research on bacterial, viral, and human-oriented projects. Among these services, the […]

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Targeted Sequencing in Bacterial Research

In the new age of genomics, researching specific genes within a genome has become a common focal point of interest. This is prevalent in bacterial research fields primarily because it provides deep insight into specific functions and attributes of the organism. Researchers across multiple fields are finding great value in honing in on specific gene […]

Multiplex Sequencing: The Fast and Cost Effective Method

The cost and speed of completing a genome sequencing run is typically the driving force behind any research requiring next generation sequencing. Most organizations have project or departmental budgets that they need to adhere to, which makes sequencing pricing a very sensitive topic. Researchers need the sequencing data but often don’t have an adequate budget […]

Cancer Gene Databases You Need

With any research, it all starts with the data. Cancer is no exception here. The incredible amount of funding that has been pushed into cancer research has produced many different databases that have identified genes that correlate with common cancers. A great first step for researchers exploring the genetic structures of these diseases is to […]